Transition metal-α-amino acid complexes with antibiotic activity against Mycobacterium spp.

Abstract

Synthetic iridium-, rhodium-, and ruthenium-amino acid complexes with hydrophobic l-amino acids have antibiotic activity against Mycobacterium spp., including Mycobacterium bovis BCG and the rapidly growing species Mycobacterium abscessus and Mycobacterium chelonae. Concentrations of transition metal-amino acid complexes demonstrating hemolysis or cytotoxicity were 10- to 25-fold higher than were the MICs.

DOI: 10.1128/AAC.00452-13

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Cite this paper

@article{Karpin2013TransitionMA, title={Transition metal-α-amino acid complexes with antibiotic activity against Mycobacterium spp.}, author={George W. Karpin and Joseph S. Merola and Joseph O . Falkinham}, journal={Antimicrobial agents and chemotherapy}, year={2013}, volume={57 7}, pages={3434-6} }