Transition from the noninvasive to the invasive phenotype and loss of alpha-catenin in human colon cancer cells.

@article{Vermeulen1995TransitionFT,
  title={Transition from the noninvasive to the invasive phenotype and loss of alpha-catenin in human colon cancer cells.},
  author={Stefan J T Vermeulen and Eric A. Bruyneel and Marc E. Bracke and Georges K P de Bruyne and Krist'l M Vennekens and Koen Vleminckx and Geert Berx and Frans van Roy and Marc M. K. Mareel},
  journal={Cancer research},
  year={1995},
  volume={55 20},
  pages={4722-8}
}
Loss of epithelioid organization in carcinoma cell lines has been related to invasiveness and poor differentiation of tumors. We investigated the invasion in vitro of various human colon cancer cell lines. Most cell lines were noninvasive into chick heart fragments, and this correlated with an epithelioid morphotype. Only cell lines COLO320DM, SW620, and variants of HCT-8 and DLD-1 were invasive and nonepithelioid. We examined in these cell lines whether invasiveness was related to changes in… CONTINUE READING