Transition from squamous cell carcinoma to adenocarcinoma in adenosquamous carcinoma of the lung.

@article{Kanazawa2000TransitionFS,
  title={Transition from squamous cell carcinoma to adenocarcinoma in adenosquamous carcinoma of the lung.},
  author={Hidemi Kanazawa and Masahito Ebina and N Ino-oka and Minoru Shimizukawa and Toshiomi Takahashi and Satoshi Fujimura and Tsutomu Izumiotsu Imai and Toshihiro Nukiwa},
  journal={The American journal of pathology},
  year={2000},
  volume={156 4},
  pages={
          1289-98
        }
}
The heterogeneity of tumor cells is frequently observed in lung cancer, but the clonality of these cells has not yet been established. The distinct components of 12 lung adenosquamous carcinomas were compared by genetic alterations of p53 and K-ras, chromosomal abnormalities at 9p21 and 9q31-32, and immunohistochemical reactions. The immunoreactivity of p53 was consistent in both adenocarcinomatous and squamous cell carcinomatous components as well as in the transitional areas, retaining the… CONTINUE READING