Transition from parenteral to oral treprostinil in pulmonary arterial hypertension.

@article{Chakinala2017TransitionFP,
  title={Transition from parenteral to oral treprostinil in pulmonary arterial hypertension.},
  author={Murali M. Chakinala and Jeremy P. Feldman and Franz P Rischard and Michael A. Mathier and Meredith Broderick and Nicole Leedom and Kevin Laliberte and Richard J. White},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2017},
  volume={36 2},
  pages={193-201}
}
BACKGROUND Parenteral prostanoids are effective treatment for pulmonary arterial hypertension, but long-term pump infusion systems have significant delivery-related safety and convenience limitations. METHODS Subjects with a favorable risk profile transitioned from parenteral to oral treprostinil using a protocol-driven titration during 5 days of inpatient observation. Baseline and Week 24 assessments included 6-minute walk distance, echocardiogram, right heart catheterization… CONTINUE READING
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