Transition from a nucleosome-based to a protamine-based chromatin configuration during spermiogenesis in Drosophila.

@article{Rathke2007TransitionFA,
  title={Transition from a nucleosome-based to a protamine-based chromatin configuration during spermiogenesis in Drosophila.},
  author={Christina Rathke and Willy M Baarends and Sunil Jayaramaiah-Raja and Marek Bartkuhn and Rainer Renkawitz and Renate Renkawitz-Pohl},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 9},
  pages={1689-700}
}
In higher organisms, the chromatin of sperm is organised in a highly condensed protamine-based structure. In pre-meiotic stages and shortly after meiosis, histones carry multiple modifications. Here, we focus on post-meiotic stages and show that also after meiosis, histone H3 shows a high overall methylation of K9 and K27 and we hypothesise that these modifications ensure maintenance of transcriptional silencing in the haploid genome. Furthermore, we show that histones are lost during the early… CONTINUE READING