Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase.

Abstract

Adenosine triphosphate phosphoribosyltransferase (ATP-PRT) catalyzes the first step in histidine biosynthesis, a pathway essential to microorganisms and a validated target for antimicrobial drug design. The ATP-PRT enzyme catalyzes the reversible substitution reaction between phosphoribosyl pyrophosphate and ATP. The enzyme exists in two structurally… (More)
DOI: 10.1021/acschembio.7b00484

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Cite this paper

@article{Moggr2017TransitionSA, title={Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase.}, author={Gert-Jan Moggr{\'e} and Myles B Poulin and Peter C Tyler and Vern L Schramm and Emily J Parker}, journal={ACS chemical biology}, year={2017}, volume={12 10}, pages={2662-2670} }