Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors

@article{Finney2003TransitionMS,
  title={Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors},
  author={Lydia A. Finney and Thomas V. O’Halloran},
  journal={Science},
  year={2003},
  volume={300},
  pages={931 - 936}
}
The essential transition metal ions are avidly accumulated by cells, yet they have two faces: They are put to use as required cofactors, but they also can catalyze cytotoxic reactions. Several families of proteins are emerging that control the activity of intracellular metal ions and help confine them to vital roles. These include integral transmembrane transporters, metalloregulatory sensors, and diffusible cytoplasmic metallochaperone proteins that protect and guide metal ions to targets. It… 
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