Transition-Metal-Free Oxidative Aliphatic C-H Azidation.


The first example of a practical and selective azidation of unactivated aliphatic C-H bonds with easily handled sulfonyl azides as azide source without the use of transition metals has been explored. This method is operationally simple, scalable, and applicable to late-stage azidation of natural products and derivatives, which make it a valuable method for the synthesis of organic azides.

DOI: 10.1021/acs.orglett.5b03001

Cite this paper

@article{Zhang2015TransitionMetalFreeOA, title={Transition-Metal-Free Oxidative Aliphatic C-H Azidation.}, author={Xiaofei Zhang and Haodong Yang and Pingping Tang}, journal={Organic letters}, year={2015}, volume={17 23}, pages={5828-31} }