Transition-Metal-Free Lactonization of sp2 C-H Bonds with CO2.


The transition-metal-free lactonization of heteroaryl and alkenyl C-H bonds with carbon dioxide is reported to synthesize important coumarin derivatives in moderate to excellent yields. These redox-neutral reactions feature a broad substrate scope, good functional group tolerance, facile scalability, and easy product derivatization. 
DOI: 10.1021/acs.orglett.6b03601


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