Transition-Metal-Free C-H Hydroxylation of Carbonyl Compounds.

  title={Transition-Metal-Free C-H Hydroxylation of Carbonyl Compounds.},
  author={Moreshwar Bhagwan Chaudhari and Yogesh B. Sutar and Shreyas Malpathak and Anirban Hazra and Boopathy Gnanaprakasam},
  journal={Organic letters},
  volume={19 13},
Transition metal and reductant free α-C(sp3)-H hydroxylation of carbonyl compounds are reported. This method is promoted by commercially available inexpensive KO-t-Bu and atmospheric air as an oxidant at room temperature. This unified strategy is also very facile for hydroxylation of various carbonyl compound derivatives to obtain quaternary hydroxyl compounds in excellent yield. A preliminary mechanistic investigation, supported by isotope labeling and computational studies, suggests the… 
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