Transit through the Flea Vector Induces a Pretransmission Innate Immunity Resistance Phenotype in Yersinia pestis

@inproceedings{Vadyvaloo2010TransitTT,
  title={Transit through the Flea Vector Induces a Pretransmission Innate Immunity Resistance Phenotype in Yersinia pestis},
  author={Viveka Vadyvaloo and Clayton Olaf Jarrett and Daniel E. Sturdevant and Florent Sebbane and B Joseph Hinnebusch},
  booktitle={PLoS pathogens},
  year={2010}
}
Yersinia pestis, the agent of plague, is transmitted to mammals by infected fleas. Y. pestis exhibits a distinct life stage in the flea, where it grows in the form of a cohesive biofilm that promotes transmission. After transmission, the temperature shift to 37 degrees C induces many known virulence factors of Y. pestis that confer resistance to innate immunity. These factors are not produced in the low-temperature environment of the flea, however, suggesting that Y. pestis is vulnerable to the… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 61 REFERENCES

Adaptive response of Yersinia pestis to extracellular effectors of innate immunity during bubonic plague.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Transmission of Yersinia pestis from an infectious biofilm in the flea vector.

  • The Journal of infectious diseases
  • 2004
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Colonization of Abiotic Surfaces.

VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Transcription factor function and promoter architecture govern the evolution of bacterial regulons.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2009
VIEW 1 EXCERPT