Transimmunization and the evolution of extracorporeal photochemotherapy.

  title={Transimmunization and the evolution of extracorporeal photochemotherapy.},
  author={Michael Girardi and Jeffrey S. Schechner and Earl J Glusac and Carole Berger and Richard L. Edelson},
  journal={Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis},
  volume={26 3},
We are now aware that extracorporeal photopheresis (ECP) - in which a patient's leukocytes are isolated, passed through an ultrathin clear plastic plate, and exposed to 8-methoxypsoralen (8-MOP) and ultraviolet A light prior to reinfusion - is a simple and efficient dendritic cell (DC) therapy and the first FDA approved selective immunotherapy for cancer. DCs, as the most effective antigen presenting cells (APCs), are central to many ongoing efforts to stimulate immune responses to cancer cells… CONTINUE READING
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