Transient weakness and altered membrane characteristic in recessive generalized myotonia (Becker)

@article{Rudel1988TransientWA,
  title={Transient weakness and altered membrane characteristic in recessive generalized myotonia (Becker)},
  author={Reinhardt Rüdel and Kenneth Ricker and Frank Lehmann-Horn},
  journal={Muscle \& Nerve},
  year={1988},
  volume={11}
}
The isometric force of arm and leg muscles was studied in five unrelated patients with recessive generalized myotonia (Becker). The symptom of myotonia was present mainly in the legs, whereas transient weakness was the prominent symptom in the arms. Tocainide improved both symptoms, although it improved the stiffness more than the weakness. A specimen of intact muscle fibers was excised from the external intercostal muscle of one of the patients. The resting potential of the fibers was normal… 
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