Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting.

@article{Shen2010TransientTB,
  title={Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting.},
  author={Kuang Shen and Shu-Ou Shan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 17},
  pages={
          7698-703
        }
}
Kinetic control of macromolecular interactions plays key roles in biological regulation. An example of such control occurs in cotranslational protein targeting by the signal recognition particle (SRP), during which the SRP RNA and the cargo both accelerate complex assembly between the SRP and SRP receptor FtsY 10(2)-fold. The molecular mechanism underlying these rate accelerations was unclear. Here we show that a highly conserved basic residue, Lys399, on the lateral surface of FtsY provides a… CONTINUE READING

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