Transient swelling, acidification, and mitochondrial depolarization occurs in neurons but not astrocytes during spreading depression.

@article{Zhou2010TransientSA,
  title={Transient swelling, acidification, and mitochondrial depolarization occurs in neurons but not astrocytes during spreading depression.},
  author={Ning Zhou and Grant R Gordon and Denise Feighan and Brian A MacVicar},
  journal={Cerebral cortex},
  year={2010},
  volume={20 11},
  pages={2614-24}
}
Cortical spreading depression (SD) is a propagating wave of neuronal and glial depolarization that manifests in several brain disorders. However, the relative contribution of neurons and astrocytes to SD genesis has remained controversial. This is in part due to a lack of utilizing sophisticated experimental methodologies simultaneously to quantify multiple cellular parameters. To address this, we used simultaneous two-photon imaging, intrinsic optical imaging, and electrophysiological… CONTINUE READING
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