Transient receptor potential vanilloid 1 channels modulate the synaptic effects of TNF-α and of IL-1β in experimental autoimmune encephalomyelitis.

@article{Musumeci2011TransientRP,
  title={Transient receptor potential vanilloid 1 channels modulate the synaptic effects of TNF-α and of IL-1β in experimental autoimmune encephalomyelitis.},
  author={Gabriele Musumeci and Giorgio Grasselli and Silvia Del Rossi and Valentina De Chiara and Alessandra Musella and Caterina Motta and Valeria Studer and Giorgio Bernardi and Nabila Haji and Helena Sepman and Diego Fresegna and Mauro Maccarrone and Georgia Mandolesi and Diego Centonze},
  journal={Neurobiology of disease},
  year={2011},
  volume={43 3},
  pages={669-77}
}
Transient receptor potential vanilloid 1 (TRPV1) channels are involved in several inflammatory diseases. However, their action is still controversial, and both pro-inflammatory and anti-inflammatory roles have been described. We used a strain of TRPV1-KO mice to characterize the role of these channels in experimental autoimmune encephalomyelitis (EAE), which models multiple sclerosis (MS) in mice. EAE mice showed higher lethality in the peak phase of the disease and a better recovery of the… CONTINUE READING