Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions.

@article{Lambert2011TransientRP,
  title={Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions.},
  author={Sachar Lambert and Anna Drews and Oleksandr Rizun and Thomas F. J. Wagner and Annette Lis and Stefanie Mannebach and Sandra Plant and Melanie Portz and Marcel Meissner and Stephan Ernst Philipp and Johannes Oberwinkler},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 14},
  pages={12221-33}
}
TRPM1 is the founding member of the melastatin subgroup of transient receptor potential (TRP) proteins, but it has not yet been firmly established that TRPM1 proteins form ion channels. Consequently, the biophysical and pharmacological properties of these proteins are largely unknown. Here we show that heterologous expression of TRPM1 proteins induces ionic conductances that can be activated by extracellular steroid application. However the current amplitudes observed were too small to enable a… CONTINUE READING

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  • T.F.J. Wagner, A. Drews, +4 authors J. Oberwinkler
  • 2010

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