Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin

@inproceedings{Grace2012TransientRP,
  title={Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin},
  author={Megan S Grace and Mark A Birrell and Eric Dubuis and Sarah A. Maher and Maria G Belvisi},
  booktitle={Thorax},
  year={2012}
}
BACKGROUND Cough is the most frequent reason for consultation with a family doctor, or with a general or respiratory physician. Treatment options are limited and a recent meta-analysis concluded that over-the-counter remedies are ineffective and there is increasing concern about their use in children. Endogenous inflammatory mediators such as prostaglandin E2 (PGE2) and bradykinin (BK), which are often elevated in respiratory disease states, are also known to cause cough by stimulating airway… CONTINUE READING

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