Transient receptor potential channels in rat renal microcirculation: actions of angiotensin II.

@article{Takenaka2002TransientRP,
  title={Transient receptor potential channels in rat renal microcirculation: actions of angiotensin II.},
  author={Tsuneo Takenaka and Hiromichi Suzuki and Hirokazu Okada and Tsutomu Inoue and Yoshihiko Kanno and Yuri Ozawa and Koichi Hayashi and Takao Saruta},
  journal={Kidney international},
  year={2002},
  volume={62 2},
  pages={558-65}
}
BACKGROUND This study assessed the calcium-activating mechanisms mediating glomerular arteriolar constriction by angiotensin II (Ang II). METHODS Immunohistochemical and physiological studies were carried out, using antibody against transient receptor potential (TRP)-1 and an isolated perfused kidney model. RESULTS Immunohistochemical experiments demonstrated that TRP-1 proteins were transcribed on both afferent and efferent arteriolar myocytes. In the first series of physiological… CONTINUE READING

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