Transient receptor potential channels in Alzheimer's disease.

@article{Yamamoto2007TransientRP,
  title={Transient receptor potential channels in Alzheimer's disease.},
  author={Shinichiro Yamamoto and Teruaki Wajima and Yuji Hara and Motohiro Nishida and Yasuo Mori},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1772 8},
  pages={958-67}
}
Cognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from the degeneration of synapses and neuronal death in the limbic system and associated regions of the cerebral cortex. An alteration in the proteolytic processing of the amyloid precursor protein (APP) results in increased production and accumulation of amyloid beta-peptide (Abeta) in the brain. Abeta can render neurons vulnerable to excitotoxicity and apoptosis by disruption of cellular Ca(2+) homeostasis and… CONTINUE READING
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