Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine.

Abstract

The large Trp gene family encodes transient receptor potential (TRP) proteins that form novel cation-selective ion channels. In mammals, 28 Trp channel genes have been identified. TRP proteins exhibit diverse permeation and gating properties and are involved in a plethora of physiologic functions with a strong impact on cellular sensing and signaling… (More)
DOI: 10.1124/pr.113.008268

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