Transient receptor potential channels as drug targets.

  title={Transient receptor potential channels as drug targets.},
  author={Dayne Y Okuhara and Albert Y Hsia and Michael Y Xie},
  journal={Expert opinion on therapeutic targets},
  volume={11 3},
The mammalian transient receptor potential (TRP) superfamily of ion channels consists of voltage-independent, non-selective cation channels that are expressed in excitable and non-excitable cells. The biologic roles of TRP channels are diverse and include vascular tone, thermosensation, irritant stimuli sensing and flow sensing in the kidney. TRP channels are a relatively new target in therapeutic drug discovery. During the past few years, pharmaceutical companies have focused their discovery… CONTINUE READING

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