Transient receptor potential channel TRPM8 agonists stimulate calcium influx and neurotensin secretion in neuroendocrine tumor cells.

@article{Mergler2007TransientRP,
  title={Transient receptor potential channel TRPM8 agonists stimulate calcium influx and neurotensin secretion in neuroendocrine tumor cells.},
  author={Stefan Mergler and Mathias Z. Strowski and Simone M. Kaiser and Thomas Plath and Yvonne Giesecke and Marleen Neumann and Hiroshi Hosokawa and Shigeo Kobayashi and Jan Michael Langrehr and Peter Neuhaus and U Pl{\"o}ckinger and Bertram J Wiedenmann and Carsten Gr{\"o}tzinger},
  journal={Neuroendocrinology},
  year={2007},
  volume={85 2},
  pages={
          81-92
        }
}
TRPM8 is a member of the melastatin-type transient receptor potential ion channel family. Activation by cold or by agonists (menthol, icilin) induces a transient rise in intracellular free calcium concentration ([Ca(2+)](i)). Our previous study demonstrated that Ca(2+)-permeable cation channels play a role in IGF-1-induced secretion of chromogranin A in human neuroendocrine tumor (NET) cell line BON [Mergler et al.: Neuroendocrinology 2006;82:87-102]. Here, we extend our earlier study by… CONTINUE READING
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