Transient receptor potential canonical channels regulate the induction of cerebellar long-term depression.

@article{Chae2012TransientRP,
  title={Transient receptor potential canonical channels regulate the induction of cerebellar long-term depression.},
  author={Hong Goo Chae and Sung Ji Ahn and Yun Hwa Hong and Wen Sheng Chang and Jun Yong Kim and Sang Jeong Kim},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 37},
  pages={
          12909-14
        }
}
In the cerebellum, synaptic strength at the synapses between parallel fibers and Purkinje cells is best known to be modulated via metabotropic glutamate receptor 1 (mGluR1)-dependent cerebellar long-term depression (LTD). An increase in intracellular calcium levels plays an important role in inducing mGluR1-dependent cerebellar LTD. Downstream of mGluR1, there are two major sources of calcium: transient receptor potential canonical (TRPC) channels and inositol trisphosphate receptors (IP(3)R… CONTINUE READING

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