Transient receptor potential canonical channels are essential for chemotactic migration of human malignant gliomas.

@article{Bomben2011TransientRP,
  title={Transient receptor potential canonical channels are essential for chemotactic migration of human malignant gliomas.},
  author={Valerie C. Bomben and Kathryn Lisa Turner and Tia-Tabitha C Barclay and Harald Sontheimer},
  journal={Journal of cellular physiology},
  year={2011},
  volume={226 7},
  pages={
          1879-88
        }
}
The majority of malignant primary brain tumors are gliomas, derived from glial cells. Grade IV gliomas, Glioblastoma multiforme, are extremely invasive and the clinical prognosis for patients is dismal. Gliomas utilize a number of proteins and pathways to infiltrate the brain parenchyma including ion channels and calcium signaling pathways. In this study, we investigated the localization and functional relevance of transient receptor potential canonical (TRPC) channels in glioma migration. We… CONTINUE READING
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