Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice.

@article{Cattaruzza2010TransientRP,
  title={Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice.},
  author={Fiore Cattaruzza and Ian Spreadbury and Marcela Miranda-Morales and Eileen F. Grady and Stephen Vanner and Nigel W Bunnett},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2010},
  volume={298 1},
  pages={G81-91}
}
The excitatory ion channel transient receptor potential ankyrin-1 (TRPA1) is prominently expressed by primary afferent neurons and is a mediator of inflammatory pain. Inflammatory agents can directly activate [e.g., hydroxynonenal (HNE), prostaglandin metabolites] or indirectly sensitize [e.g., agonists of protease-activated receptor (PAR(2))] TRPA1 to induce somatic pain and hyperalgesia. However, the contribution of TRPA1 to visceral pain is unknown. We investigated the role of TRPA1 in… CONTINUE READING

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