Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells

@article{Wagner2008TransientRP,
  title={Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic $\beta$ cells},
  author={Thomas F.J. Wagner and Sabine Loch and Sachar Lambert and Isabelle Straub and Stefanie Mannebach and Ilka Mathar and Martina D{\"u}fer and Annette Lis and Veit Flockerzi and Stephan Ernst Philipp and Johannes Oberwinkler},
  journal={Nature Cell Biology},
  year={2008},
  volume={10},
  pages={1421-1430}
}
Transient receptor potential (TRP) cation channels are renowned for their ability to sense diverse chemical stimuli. Still, for many members of this large and heterogeneous protein family it is unclear how their activity is regulated and whether they are influenced by endogenous substances. On the other hand, steroidal compounds are increasingly recognized to have rapid effects on membrane surface receptors that often have not been identified at the molecular level. We show here that TRPM3, a… 

Steroids and TRP Channels: A Close Relationship

Transient receptor potential channels are remarkable transmembrane protein complexes that are essential for the physiology of the tissues in which they are expressed and are subject to being affected by several endogenously-produced compounds.

Signal transduction via TRPM3 channels in pancreatic β-cells.

The view that TRPM3 represents an ionotropic steroid receptor of pancreatic β-cells linking insulin release with steroid hormone signaling is discussed and a direct effect of TR PM3 stimulation on insulin secretion has been reported.

Transient Receptor Potential Melastatin 1 (TRPM1) Is an Ion-conducting Plasma Membrane Channel Inhibited by Zinc Ions*

It is shown that heterologous expression of TRPM1 proteins induces ionic conductances that can be activated by extracellular steroid application, and it is demonstrated that TR PM1 proteins are bona fide ion-conducting plasma membrane channels.

Transient receptor potential cation channels in pancreatic β cells.

This review will focus on cation channels from the melastatin TRP -subfamily and discuss how TRPM channels can influence Ca(2+) signaling in β cells, and critically discuss the use of mouse models for the unraveling of basic mechanisms of insulin release.

Molecular Regulations and Functions of the Transient Receptor Potential Channels of the Islets of Langerhans and Insulinoma Cells

This review briefly compiles the current knowledge about the molecular mechanisms of regulations, and functions of the TRP channels in the β-cells, the α- cells, and some insulinoma cell lines.

Carboxamido steroids inhibit the opening properties of transient receptor potential ion channels by lipid raft modulation[S]

Transient Receptor Potential (TRP) cation channels, like the TRP Vanilloid 1 (TRPV1) and TRP Ankyrin 1 (TRPA1), are expressed on primary sensory neurons. These thermosensor channels play a role in

Regulation of TRP channels by steroids: Implications in physiology and diseases.

The Role of TRP Proteins in Mast Cells

Current knowledge about the expression of individual Trp genes with the majority of the 28 members being yet identified in different mast cell models are summarized, and mechanisms how they can regulate mast cell functions are highlighted.
...

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