Transient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerve.

@article{Sakatani1992TransientPA,
  title={Transient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerve.},
  author={Kazuomi Sakatani and J Andrew Black and Jeffery D Kocsis},
  journal={Proceedings. Biological sciences},
  year={1992},
  volume={247 1319},
  pages={155-61}
}
GABA (gamma-aminobutyric acid) is a major inhibitory synaptic neurotransmitter with widespread distribution in the central nervous system (CNS). GABA can also modulate axonal excitability by activation of GABAA receptors in CNS white matter regions where synapses and neuronal cell bodies are not present. Studies on cultured glia cells have revealed the synthesis of GABA in rat optic nerve O-2A progenitor cells that give rise to oligodendrocytes and type 2 astrocytes in vitro. We report here… CONTINUE READING

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