Transient perturbation of endothelial integrity induced by natural antibodies and complement

@article{Saadi1995TransientPO,
  title={Transient perturbation of endothelial integrity induced by natural antibodies and complement},
  author={Sihem Saadi and Jeffrey L Platt},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={181},
  pages={21 - 31}
}
The barrier function of blood vessels is though to be regulated at least in part by endothelium. This concept is supported by the dramatic loss of barrier function occurring in the hyperacute rejection of vascularized grafts mediated by anti-endothelial cell (EC) antibodies and complement. In this process, the endothelium is not destroyed but instead loses the ability to retain blood cells and plasma proteins within capillaries. The noncytotoxic mechanism that allows this change in EC function… CONTINUE READING

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