Transient over-expression of estrogen receptor-α in breast cancer cells promotes cell survival and estrogen-independent growth

@article{Tolhurst2010TransientOO,
  title={Transient over-expression of estrogen receptor-α in breast cancer cells promotes cell survival and estrogen-independent growth},
  author={Robert S. Tolhurst and Ross S. Thomas and Fiona J. Kyle and Hetal Patel and Manikandan Periyasamy and Andrew Photiou and Paul T. R. Thiruchelvam and C Lai and Marwa Al-sabbagh and Rosemary Ann Fisher and Sayka Barry and Tatjana Crnogorac-Jurcevic and Lesley-Ann Martin and Mitch Dowsett and R C Coombes and Tahereh Kamalati and Simak Ali and Laki Buluwela},
  journal={Breast Cancer Research and Treatment},
  year={2010},
  volume={128},
  pages={357-368}
}
Estrogen receptor-α (ERα) positive breast cancer frequently responds to inhibitors of ERα activity, such as tamoxifen, and/or to aromatase inhibitors that block estrogen biosynthesis. However, many patients become resistant to these agents through mechanisms that remain unclear. Previous studies have shown that expression of ERα in ERα-negative breast cancer cell lines frequently inhibits their growth. In order to determine the consequence of ERα over-expression in ERα-positive breast cancer… CONTINUE READING

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