Transient-outward K+ channel inhibition facilitates L-type Ca2+ current in heart.

@article{Wang2006TransientoutwardKC,
  title={Transient-outward K+ channel inhibition facilitates L-type Ca2+ current in heart.},
  author={Yanggan Wang and Jun Cheng and Samvit Tandan and Minjie Jiang and Diana T McCloskey and Joseph A Hill},
  journal={Journal of cardiovascular electrophysiology},
  year={2006},
  volume={17 3},
  pages={298-304}
}
BACKGROUND Transient outward current (I(to)) and L-type calcium current (I(Ca)) are important repolarization currents in cardiac myocytes. These two currents often undergo disease-related remodeling while other currents are spared, suggesting a functional coupling between them. Here, we investigated the effects of I(to) channel blockers, 4-aminopyridine (4-AP) and heteropodatoxin-2 (HpTx2), on I(Ca) in cardiac ventricular myocytes. METHODS AND RESULTS I(Ca) was recorded in enzymatically… CONTINUE READING