Transient optogenetic inactivation of the medial entorhinal cortex biases the active population of hippocampal neurons.

@article{Rueckemann2016TransientOI,
  title={Transient optogenetic inactivation of the medial entorhinal cortex biases the active population of hippocampal neurons.},
  author={Jon W. Rueckemann and A J Dimauro and Lara M. Rangel and Xue Han and Edward S. Boyden and Howard Eichenbaum},
  journal={Hippocampus},
  year={2016},
  volume={26 2},
  pages={246-60}
}
The mechanisms that enable the hippocampal network to express the appropriate spatial representation for a particular circumstance are not well understood. Previous studies suggest that the medial entorhinal cortex (MEC) may have a role in reproducibly selecting the hippocampal representation of an environment. To examine how ongoing MEC activity is continually integrated by the hippocampus, we performed transient unilateral optogenetic inactivations of the MEC while simultaneously recording… CONTINUE READING
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