Transient neonatal hypothyroidism: characterization of maternal antibodies to the thyrotropin receptor.

@article{Zakarija1990TransientNH,
  title={Transient neonatal hypothyroidism: characterization of maternal antibodies to the thyrotropin receptor.},
  author={M. Zakarija and J Maxwell McKenzie and Margaret S. Eidson},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1990},
  volume={70 5},
  pages={1239-46}
}
Transient neonatal thyroid disease is known to occur as a result of transplacental passage of maternal immunoglobulin G (IgG) that contains antibodies to the TSH receptor (TRAb). Thyroid-stimulating antibody (TSAb) produces hyperthyroidism, and antibody that blocks TSH binding (TBIAb) results in hypothyroidism. We have analyzed in detail the IgG from four women who gave birth to children with transient neonatal hypothyroidism and have shown stimulating and inhibiting antibodies to coexist in… CONTINUE READING