Transient neonatal high oxygen exposure leads to early adult cardiac dysfunction, remodeling, and activation of the renin-angiotensin system.

@article{Bertagnolli2014TransientNH,
  title={Transient neonatal high oxygen exposure leads to early adult cardiac dysfunction, remodeling, and activation of the renin-angiotensin system.},
  author={Mariane Bertagnolli and Fanny Huyard and Anik Cloutier and Zackary Anstey and Julie-{\'E}milie Huot-Marchand and Catherine Fallaha and Pierre Paradis and Ernesto L Schiffrin and Denis Deblois and Anne Monique Nuyt},
  journal={Hypertension},
  year={2014},
  volume={63 1},
  pages={143-50}
}
Perinatal conditions (such as preterm birth) can affect adult health and disease, particularly the cardiovascular system. Transient neonatal high O(2) exposure in rat in adulthood (a model of preterm birth-related complications) leads to elevated blood pressure, vascular rigidity, and dysfunction with renin-angiotensin system activation. We postulate that neonatal hyperoxic stress also affects myocardial structure, function, and expression of renin-angiotensin system components. Sprague-Dawley… CONTINUE READING
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