Transient myeloproliferative disorder in children with Down syndrome: clarity to this enigmatic disorder

@article{Gamis2012TransientMD,
  title={Transient myeloproliferative disorder in children with Down syndrome: clarity to this enigmatic disorder},
  author={Alan S. Gamis and Franklin O. Smith},
  journal={British Journal of Haematology},
  year={2012},
  volume={159}
}
  • A. Gamis, F. Smith
  • Published 1 November 2012
  • Medicine
  • British Journal of Haematology
Children with trisomy 21 have a unique predisposition to develop a megakaryoblastic proliferative disease of varying severity during their first 3 months of life. This disorder exists in no other children or adults without the presence of trisomy 21 and only occurs in the fetal or neonatal period of life. Its spontaneous resolution in most cases further delineates it from otherwise indistinguishable neonatal leukaemias. The identification that GATA1 mutations are the leukaemogenic source along… 
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  • 2014
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The molecular basis for DS-TAM/ML-DS remained mysterious for a long period of time, but new genetic insights have been gained over the past 12 years that have begun to decipher the pathophysiology of this unusual disorder.
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    Pediatrics international : official journal of the Japan Pediatric Society
  • 2019
TLDR
Investigation of TAM, a unique pre‐leukemic condition, will continue to strongly influence basic and clinical research into the development of hematological malignancies.
Neonatal vesiculopustular eruption in Down syndrome and transient myeloproliferative disorder: A case report and review of the literature
TLDR
The case of a male infant with DS and TMD, associated with a vesiculopustular eruption, which appeared on day 36 of life is described.
A Novel GATA-1 Mutation in a Neonate with Transient Abnormal Myelopoiesis without Down Syndrome
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A case of TAM with a novel mutation in the GATA-1 gene, involving a newborn boy found to have leukocytosis with 50% myeloid blast forms, implying premature termination is reported.
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