Transient myeloproliferative disorder in children with Down syndrome: clarity to this enigmatic disorder
@article{Gamis2012TransientMD, title={Transient myeloproliferative disorder in children with Down syndrome: clarity to this enigmatic disorder}, author={A. Gamis and F. O. Smith}, journal={British Journal of Haematology}, year={2012}, volume={159} }
Children with trisomy 21 have a unique predisposition to develop a megakaryoblastic proliferative disease of varying severity during their first 3 months of life. This disorder exists in no other children or adults without the presence of trisomy 21 and only occurs in the fetal or neonatal period of life. Its spontaneous resolution in most cases further delineates it from otherwise indistinguishable neonatal leukaemias. The identification that GATA1 mutations are the leukaemogenic source along… CONTINUE READING
Topics from this paper
53 Citations
Transient Myeloproliferative Disorder in Neonates with Down syndrome: Case Report and Review
- Medicine
- 2018
- PDF
Transient Abnormal Myelopoiesis: A Varied Spectrum of Clinical Presentation
- Medicine
- Journal of hematology
- 2017
- 4
- Highly Influenced
- PDF
Presentation of Acute Megakaryoblastic Leukemia Associated with a GATA‐1 Mutation Mimicking the Eruption of Transient Myeloproliferative Disorder
- Medicine
- Pediatric dermatology
- 2015
- 1
- Highly Influenced
Recent advances in the understanding of transient abnormal myelopoiesis in Down syndrome
- Medicine
- Pediatrics international : official journal of the Japan Pediatric Society
- 2019
- 12
References
SHOWING 1-10 OF 91 REFERENCES
Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971.
- Medicine
- Blood
- 2011
- 138
Vesiculopustular eruptions in Down syndrome neonates with myeloproliferative disorders.
- Medicine
- Archives of dermatology
- 2001
- 39
- PDF
Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome.
- Biology, Medicine
- Blood
- 2009
- 199
Transient Myeloproliferative Disorder Causing a Vesiculopustular Eruption in a Phenotypically Normal Neonate
- Medicine
- Pediatric dermatology
- 2004
- 27
Immunophenotype of a transient myeloproliferative disorder in a newborn with trisomy 21.
- Biology, Medicine
- Cytometry
- 2000
- 19
Analysis of GATA1 mutations in Down syndrome transient myeloproliferative disorder and myeloid leukemia.
- Medicine
- Blood
- 2011
- 72
- Highly Influential
Leukemia and/or myeloproliferative syndrome in neonates with Down syndrome.
- Medicine
- Seminars in perinatology
- 1997
- 128
Transient leukaemia – a benign form of leukaemia in newborn infants with trisomy 21
- Biology, Medicine
- British journal of haematology
- 2003
- 185
Neonatal leukemoid reaction. An isolated manifestation of mosaic trisomy 21.
- Medicine
- American journal of diseases of children
- 1982
- 54
Incidence and Treatment of Potentially Lethal Diseases in Transient Leukemia of Down Syndrome: Pediatric Oncology Group Study
- Medicine
- Journal of pediatric hematology/oncology
- 2002
- 110