Transient myeloproliferative disorder in children with Down syndrome: clarity to this enigmatic disorder

  title={Transient myeloproliferative disorder in children with Down syndrome: clarity to this enigmatic disorder},
  author={A. Gamis and F. O. Smith},
  journal={British Journal of Haematology},
  • A. Gamis, F. O. Smith
  • Published 2012
  • Medicine
  • British Journal of Haematology
  • Children with trisomy 21 have a unique predisposition to develop a megakaryoblastic proliferative disease of varying severity during their first 3 months of life. This disorder exists in no other children or adults without the presence of trisomy 21 and only occurs in the fetal or neonatal period of life. Its spontaneous resolution in most cases further delineates it from otherwise indistinguishable neonatal leukaemias. The identification that GATA1 mutations are the leukaemogenic source along… CONTINUE READING
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