Transient-mediated fate determination in a transcriptional circuit of HIV

Abstract

Steady-state behavior and bistability have been proposed as mechanisms for decision making in gene circuits. However, transient gene expression has also been proposed to control cell fate, with the decision arbitrated by the duration of a transient gene expression pulse. Here, using an HIV-1 model system, we directly quantify transcriptional feedback… (More)
DOI: 10.1038/ng.116

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