Transient loss of microtubule-associated protein 2 immunoreactivity after moderate brain injury in mice.

@article{Huh2003TransientLO,
  title={Transient loss of microtubule-associated protein 2 immunoreactivity after moderate brain injury in mice.},
  author={Jimmy W Huh and Ramesh Raghupathi and Helmut L. Laurer and Mark A. Helfaer and Kathryn E. Saatman},
  journal={Journal of neurotrauma},
  year={2003},
  volume={20 10},
  pages={975-84}
}
Microtubule-associated protein 2 (MAP2) is important for microtubule stability and neural plasticity and appears to be among the most vulnerable of the cytoskeletal proteins under conditions of neuronal injury. To evaluate the acute effects of moderate severity traumatic brain injury on MAP2, anesthetized, adult male C57BL/6 mice were subjected to controlled cortical impact brain injury. At 5 min, 15 min, 90 min, 4 h, and 24 h following brain injury (n = 4 injured and n = 1 sham-injured per… CONTINUE READING