Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.

@article{Loukogeorgakis2007TransientLI,
  title={Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism.},
  author={Stavros P. Loukogeorgakis and Rupert P. Williams and Anna T Panagiotidou and Shyamsunder K Kolvekar and Ann Donald and Tim James Cole and Derek M Yellon and John Eric Deanfield and Raymond J Macallister},
  journal={Circulation},
  year={2007},
  volume={116 12},
  pages={1386-95}
}
BACKGROUND Transient limb ischemia administered before a prolonged ischemic insult has systemic protective effects against ischemia-reperfusion (IR) injury (remote ischemic preconditioning [RIPC]). It has been demonstrated that protection from IR can be achieved by brief periods of ischemia applied at a remote site during an injurious ischemic event (remote postconditioning [RPostC]). Using an in vivo model of endothelial IR injury, we sought to determine whether RPostC occurred in humans and… CONTINUE READING

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