Transient intercellular adhesion: the importance of weak protein-protein interactions.


Intercellular adhesion is a complex phenomenon central to the development, structure and functioning of all multicellular organisms. Adhesion is mediated by distinct families of cell-adhesion molecules (CAMs), and recent studies have identified key characteristics of CAMs that influence their function. Affinity and kinetic analyses using a novel technique based on surface plasmon resonance have shown that CAM interactions that mediate transient cell adhesion may have surprisingly low affinities and extremely fast dissociation rate constants.


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@article{Merwe1994TransientIA, title={Transient intercellular adhesion: the importance of weak protein-protein interactions.}, author={Philip Anton van der Merwe and A. Neil Barclay}, journal={Trends in biochemical sciences}, year={1994}, volume={19 9}, pages={354-8} }