Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.

@article{Kimura2008TransientIO,
  title={Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.},
  author={Hiromichi Kimura and Jessica M. Y. Ng and Tom Curran},
  journal={Cancer cell},
  year={2008},
  volume={13 3},
  pages={249-60}
}
The Hedgehog (Hh) pathway plays critical roles in normal development and in tumorigenesis. We generated Gli-luciferase transgenic mice to evaluate the Smo inhibitor, HhAntag, by whole animal functional imaging. HhAntag rapidly reduced systemic luciferase activity in 10- to 14-day-old mice following oral dosing. Although pathway activity was restored 2 days… CONTINUE READING