Transient infection of the zebrafish notochord with E. coli induces chronic inflammation

  title={Transient infection of the zebrafish notochord with E. coli induces chronic inflammation},
  author={Mai Nguyen-Chi and Quang Tien Phan and Catherine Gonzalez and J F Dubremetz and Jean-Pierre Levraud and Georges Lutfalla},
  booktitle={Disease models & mechanisms},
Zebrafish embryos and larvae are now well-established models in which to study infectious diseases. Infections with non-pathogenic Gram-negative Escherichia coli induce a strong and reproducible inflammatory response. Here, we study the cellular response of zebrafish larvae when E. coli bacteria are injected into the notochord and describe the effects. First, we provide direct evidence that the notochord is a unique organ that is inaccessible to leukocytes (macrophages and neutrophils) during… CONTINUE READING
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