Corpus ID: 34842760

Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea in human glioma cells.

@article{Gomi1997TransientIO,
  title={Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea in human glioma cells.},
  author={A. Gomi and S. Shinoda and T. Masuzawa and T. Ishikawa and M. T. Kuo},
  journal={Cancer research},
  year={1997},
  volume={57 23},
  pages={
          5292-9
        }
}
  • A. Gomi, S. Shinoda, +2 authors M. T. Kuo
  • Published 1997
  • Medicine, Biology
  • Cancer research
  • Treatment of human glioma A172 cells with 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU), an alkylating antitumor agent the primary target of which has been thought to be DNA, resulted in elevated expression of mRNA for multidrug resistance-associated protein (MRP) within the first 2 h and then a decrease in expression 24 h after the treatment. Western blot analyses revealed that levels of MRP in these ACNU-treated cells paralleled mRNA levels. Membrane vesicles… CONTINUE READING
    4-Nitroquinoline 1-oxide forms 8-hydroxydeoxyguanosine in human fibroblasts through reactive oxygen species.
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