Transient induction of lytic Kaposi's sarcoma-associated herpesvirus (KSHV) genes in KSHV-infected endothelial cells exposed to hypoxia

@inproceedings{Velasco2009TransientIO,
  title={Transient induction of lytic Kaposi's sarcoma-associated herpesvirus (KSHV) genes in KSHV-infected endothelial cells exposed to hypoxia},
  author={Pilar Gonz{\'a}lez Velasco and Lydia Dutcher and D L Davis and Robert Yarchoan},
  booktitle={Infectious Agents and Cancer},
  year={2009}
}
Kaposi's sarcoma-associated herpesvirus (KSHV), also called human herpesvirus-8 (HHV-8) is the causative agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and a form of multicentric Castleman's disease (MCD). Two of these tumors, KS and PEL, tend to arise in areas of the body that are relatively hypoxic. Exploring this phenomenon, our group has previously found that KSHV in PEL tumor cell lines is activated to lytic replication by hypoxia and that certain KSHV genes are activated… CONTINUE READING
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