Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood.

@article{Cras2004TransientIO,
  title={Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood.},
  author={Timothy D Le Cras and William D Hardie and Gail Deutsch and Kurt H. Albertine and Machiko Ikegami and Jeffrey A. Whitsett and Thomas R. Korfhagen},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2004},
  volume={287 4},
  pages={L718-29}
}
Clinical studies have associated increased transforming growth factor (TGF)-alpha and EGF receptor with lung remodeling in diseases including bronchopulmonary dysplasia (BPD). BPD is characterized by disrupted alveolar and vascular morphogenesis, inflammation, and remodeling. To determine whether transient increases in TGF-alpha are sufficient to disrupt postnatal lung morphogenesis, we utilized neonatal transgenic mice conditionally expressing TGF-alpha. Expression of TGF-alpha from postnatal… CONTINUE READING