Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver.

@article{Kay1997TransientIW,
  title={Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver.},
  author={Maria A Kay and Leonard A Meuse and Allen M. Gown and Peter Linsley and Diane Hollenbaugh and Alejandro Aruffo and Hans D. Ochs and Christopher B Wilson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 9},
  pages={
          4686-91
        }
}
Although recombinant adenovirus vectors offer a very efficient means by which to transfer genetic information into cells in vivo, antigen-dependent immunity limits the duration of gene expression and prevents retreatment. Recombinant murine CTLA4Ig and anti-CD40 ligand antibody block costimulatory interactions between T cells and antigen presenting cells. We previously reported that murine CTLA4Ig prolongs adenoviral-mediated gene transfer, but does not allow for secondary expression after… CONTINUE READING

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Kay et al

  • A. Lieber, He, +4 authors 8944–8960. Medical Sciences
  • Proc. Natl. Acad. Sci. USA 94
  • 1997
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