Transient glucose intolerance in rats after a single injection of serum from a diabetic patient with an unusual insulin resistance.

@article{Day1983TransientGI,
  title={Transient glucose intolerance in rats after a single injection of serum from a diabetic patient with an unusual insulin resistance.},
  author={P Fainstein Day and JamesA. Fagin and Robert A. Gutman},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={1983},
  volume={37 7},
  pages={
          354-7
        }
}
The single intravenous injection to rats of 1 ml of serum from an insulin resistant patient without an excessive titre of insulin antibodies (total extractable insulin levels: 0.8 U/l, serum insulin binding capacity: 1.58 U/l) and no demonstrable insulin receptor antibodies, produced fasting hyperglycemia in the animals on the fourth day following the injection (FPG: 212 +/- 35 mg %). On the 7th day the FPG returned to normal but the IVGTT was still pathological. After 14 days there was… CONTINUE READING