Transient global brain hypoxia-ischemia in adult rats: neuronal damage, glial proliferation, and alterations in inositol phospholipid hydrolysis.

@article{Fortuna1997TransientGB,
  title={Transient global brain hypoxia-ischemia in adult rats: neuronal damage, glial proliferation, and alterations in inositol phospholipid hydrolysis.},
  author={Stefano Fortuna and S. Pestalozza and Paola Lorenzini and Guillermo Mario Bisso and Luca Morelli and Hanna Michalek},
  journal={Neurochemistry international},
  year={1997},
  volume={31 4},
  pages={563-9}
}
A model of ischemic-hypoxic brain injury which combines bilateral occlusion of common carotid arteries for 10 min and mild hypoxia (15% O2 for 10 min before and during occlusion) was developed. Global ischemia was assessed by a simplified EEG recording indicating isoelectric line, i.e. full arrest of cortical electrical activity. Histological examination of brain 7 days after ischemic insult showed from moderate to severe damage, mainly in the cerebral cortex (layers III, V and VI) and… CONTINUE READING