Transient gene expression by nonintegrating lentiviral vectors.

  title={Transient gene expression by nonintegrating lentiviral vectors.},
  author={Sarah J Nightingale and Roger P Hollis and Karen A. Pepper and Denise Petersen and Xiao-jin Yu and Catherine Yang and Ingrid Bahner and Donald B Kohn},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={13 6},
Nonintegrating lentiviral (NIL) vectors were produced from HIV-1-based lentiviral vectors by introducing combinations of mutations made to disable the integrase protein itself and to alter the integrase recognition sequences (att) in the viral LTR. NIL vectors with these novel combinations of mutations were used to transduce the human T lymphoid cell line Jurkat and primary human CD34(+) hematopoietic progenitor cells to assess their efficacy measured through transient expression of the… CONTINUE READING
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