Transient gain of effector function by CD8+ T cells undergoing peripheral tolerance to high-dose self-antigen.

@article{Huang2004TransientGO,
  title={Transient gain of effector function by CD8+ T cells undergoing peripheral tolerance to high-dose self-antigen.},
  author={Xiaopei Huang and Yiping Yang},
  journal={European journal of immunology},
  year={2004},
  volume={34 5},
  pages={1351-60}
}
Induction of peripheral T cell tolerance is mediated by bone marrow-derived dendritic cells that cross-present self-antigen to self-reactive T cells. The current model for peripheral CD8(+) T cell tolerance is that TCR engagement by self-antigen in the absence of costimulation results in abortive activation without development of effector function. Here we… CONTINUE READING