Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation.

@article{Yang2008TransientFC,
  title={Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation.},
  author={Wei Yang and Huaxin Sheng and David Sjoquist Nick Warner and Wulf Paschen},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2008},
  volume={28 5},
  pages={892-6}
}
This study was designed to investigate whether small ubiquitin-like modifier (SUMO) conjugation is activated after focal cerebral ischemia. Transient ischemia induced a dramatic increase in SUMO2/3 protein conjugates. The most pronounced changes were found in the parietal cortex. SUMO2/3 conjugation was particularly high in neurons located at the border of the middle cerebral artery territory where sumoylated proteins translocated to the nucleus. Considering the marked effect of SUMO… CONTINUE READING

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